prcd-PRA & OptiGen

In early 2004 a new DNA test for prcd-PRA was made available by OptiGen in the United States.  We are pleased to say that our small kennel were the second UK kennel to OptiGen test all our dogs in May 2004.

Since that time we have tested all our dogs (apart from the ones that have two Normal/Clear tested parents.)  Although we have tested all our dogs, only the dogs forming part of our breeding programme are listed on this page, for our other dogs results please see their own pages.

With recessive conditions like PRA, there are 3 genetic categories, affected, normal and carriers. Affected animals have two copies of the faulty PRA gene, one inherited from each parent. Carrier animals have one faulty copy of the PRA gene but appear perfectly healthy and cannot be distinguished from normal dogs by eye screening. Normal animals are entirely free of the faulty gene.

The problem with relying on the KC/BVA Scheme is that breeders have no way of identifying which category their breeding stock falls into as the BVA Panellist examining the dogs eyes can only determine if a dog is clinically clear of the disease at the time of examination.  If the dog is not showing any signs of PRA at the time of the examination, the KC/BVA test cannot determine whether the dog is a carrier or whether the dog is affected and will go on to develop the disease at some time in the future. 

All our dogs are tested & we are pleased to say that we have no affected dogs.  Clear/Normal (A1) dogs will never develop the disease and are not carriers of prcd PRA & can't pass this disease onto their offspring. Carrier (B1) dogs will also never develop this disease & provided they are mated to Normal/Clear dogs, none of their offspring will develop the disease either. 

Breeding with "carrier" dogs has been only undertaken with "normal/clear" partners, this has ensured that no "affected" offspring have been produced. Puppies resulting from this combination have been OptiGen tested.  With the WISE use of this test, mating "carriers" to "normal/clear" is not a problem.

Every breed needs genetic diversity, restricting breeding's to "normal/clear" x "normal/clear" will result in the loss of many otherwise beneficial bloodlines.  The OptiGen test enables breeders to rid their lines of the possibility of producing affected animals without losing other desirable attributes, it is vitally important not to lose quality within the gene pool whilst eradicating any disease.

Offspring resulting from the mating of two "normal/clear" parents will automatically be "homozygous normal" for prcd-PRA.

For more information about OptiGen, please click here!

Breeding Strategies

Results using the OptiGen prcd test

Genotype Risk Group Significance For Breeding Risk of prcd Disease
(A1) Homozygous Normal Normal/Clear Can be bred to any dog. Will never produce affected pups. Will never develop prcd- PRA
(B1) Heterozygous Carrier Should be bred only to Normal/
Clear to remove risk of producing
affecteds
Will never develop prcd- PRA
(C1) Homozygous Mutant Affected Should be bred only to Normal/
Clear to remove risk of producing
affecteds
Very high chance of developing prcd- PRA

 

Expected results for breeding strategies using the OptiGen prcd test

Parent 1
Status
Parent 2 Status
Normal/Clear Carrier Affected
(A1) Normal/Clear All = Normal/Clear (A1) 1/2 = Normal/Clear (A1)
1/2 = Carrier (B1)
All = Carrier (B1)
(B1) Carrier 1/2 = Normal/Clear (A1)
1/2 = Carrier (B1)
1/4 = Normal/Clear (A1)
1/2 = Carrier (B1)
1/4 = Affected (C1)
1/2 = Carrier (B1)
1/2 = Affected (C1)
(C1) Affected All = Carrier (B1) 1/2 = Carrier (B1)
1/2 = Affected (C1)
All = Affected (C1)

Powerscourt OptiGen prcd-PRA Results

   

All of our dogs have been either tested by OptiGen or are from parents who are both prcd-PRA Clear/Normal which means that they can not be anything other than prcd-PRA Normal/Clear themselves.     

 

Name:

Details:

Result:

Powerscourt Enchantress - Buttons

Genotype via parentage

Homozygous Normal/Clear

Powerscourt Higher Echelon - Toby

OptiGen DNA Test

Homozygous Normal/Clear

Powerscourt Paint Splash - Tiggy

OptiGen DNA Test

Heterozygous Carrier

Powerscourt Perdita - Purdie

OptiGen DNA Test

Heterozygous Carrier

Powerscourt Perfect Gift - Maddie

OptiGen DNA Test

Heterozygous Carrier

Powerscourt Perfect Love - Minty

Genotype via parentage

Homozygous Normal/Clear

Powerscourt Perfect Magic - Dudley

Genotype via parentage

Homozygous Normal/Clear

Powerscourt Pingu - Stan

Genotype via parentage

Homozygous Normal/Clear

Powerscourt Pippi's Gift - Katie

OptiGen DNA Test

Homozygous Normal/Clear

Powerscourt Playboy - Louis

OptiGen DNA Test

Heterozygous Carrier

Powerscourt Power Of Love JW - Lottie

OptiGen DNA Test

Homozygous Normal/Clear

Powerscourt Precious Gift - Kea

Genotype via parentage

Homozygous Normal/Clear

Powerscourt Prelude - Henry

Genotype via parentage

Homozygous Normal/Clear

Powerscourt Pure Love - Willow

Genotype via parentage

Homozygous Normal/Clear

Powerscourt Pure Magic - Phoebe

OptiGen DNA Test

Homozygous Normal/Clear

Powerscourt Pure Silk - Sophie

Genotype via parentage

Homozygous Normal/Clear

Powerscourt Spice Of Life - Rosie

OptiGen DNA Test

Homozygous Normal/Clear

Riondel Venture to Powerscourt - Archie

OptiGen DNA Test

Homozygous Normal/Clear

Sorbrook Blue Ribbon at Powerscourt - Bramble

OptiGen DNA Test

Heterozygous Carrier

Spendles Spinnet of Powerscourt - Tilly

OptiGen DNA Test

Homozygous Normal/Clear

Wakehurst Playboy - Fudge

OptiGen DNA Test

Homozygous Normal/Clear

For a list of results for all dogs (all Cocker Spaniels, not just Powerscourt cockers) tested  please click here! Please note, the results currently listed for our dogs are only the results of dogs still connected to our breeding programme and have been submitted voluntarily).  From the 1st July the Kennel Club will automatically update the list with test results.

The information contained on this page is copyright to Powerscourt Cocker Spaniels.  It must not be reproduced in any shape or form.

 
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